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A single missing gene leads to miscarriage

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A single gene of the mother plays such a crucial role in the development of the placenta that its dysfunction leads to miscarriages. Researchers have observed this in so-called knockout mice that were specifically modified for this purpose. These mice lack the gene for the transcription factor Math6. By conducting further analyses, the research team is now hoping to gain new insights into the role the gene plays in recurrent miscarriage in humans.