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Regular cannabis users require up to 220% higher dosage for sedation in medical procedures

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Researchers in Colorado examined medical records of 250 patients who received endoscopic procedures after 2012, when the state legalized recreational cannabis. They found patients who smoked or ingested cannabis on a daily or weekly basis required 14% more fentanyl, 20% more midazolam, and 220% more propofol to achieve optimum sedation for routine procedures, including colonoscopy.

Source: sciencedaily.com