Perfluoroalkyl substances (PFASs) have received intense scrutiny in recent years because of their persistence in the environment and potential endocrine-disrupting effects. However, their estrogenic activities are controversial, with different studies showing apparently contradictory results. Now, researchers have used a combination of laboratory experiments and computer modeling to reveal that PFASs can interact with the estrogen receptor in different ways to influence estrogen-controlled gene expression.
