About 1 in 3 diabetic patients develops diabetic retinopathy (DR), which can impair vision and lead to blindness. A new study provides clear evidence that high glucose increases the levels of enzymatic precursor — lysyl oxidase propeptide (LOX-PP) — that promotes cell death, which was verified in an animal model of diabetes. These findings may help develop novel DR treatments by targeting LOX-PP or its metabolites.
