If necessity is the mother of invention, frustration is the father. When scientists kept running into aggravating problems with the existing tools and methods they were using to perform genetic engineering experiments, they decided to make better ones. They teamed up and created an integrated pipeline called STAMPScreen that combines novel algorithms, a new gene cloning technique, and powerful next-generation sequencing technology to help scientists get from a database to results quickly, easily, and frustration-free.