Cells have a clever way called clathrin-mediated endocytosis to transport cargos like growth factors across the cell membrane and into the cell. Researchers used a sophisticated fluorescence microscopy imaging called STAR microscopy to follow clathrin-coated vesicle formation in living cells from initiation to completion, over periods up to 100 seconds. Their study supports the flexible model of clathrin-coated vesicle formation, which includes both the constant-curvature and the flat-to-curved transition pathways.
