![improved chemokine homing enhances car t cell therapy for osteosarcoma](https://utterbuzz.com/wp-content/uploads/2024/08/improved-chemokine-homing-enhances-car-t-cell-therapy-for-osteosarcoma-640x427.jpg)
Investigators identified a chemokine/chemokine receptor mismatch for osteosarcoma (i.e., osteosarcomas secrete chemokines for which CAR T cells do not express receptors). The researchers modified CAR T cells targeting the osteosarcoma antigen B7-H3 to express CXCR2 or CXCR6 receptors, which recognize chemokines (CXCL8 or CXCL16) secreted by osteosarcoma.