![flu interferon gamma from t follicular helper cells is required to create lung resident memory b cells flu interferon gamma from t follicular helper cells is required to create lung resident memory b cells](https://utterbuzz.com/wp-content/uploads/2023/09/flu-interferon-gamma-from-t-follicular-helper-cells-is-required-to-create-lung-resident-memory-b-cells-640x481.jpg)
During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.