Microscopes are an important tool in biomedical research as it allows for detailed observation and imaging of tissues. Since biological materials are opaque by their nature, severe light scattering occurs as light travels through tissues, which induces a high level of background noise and complex optical aberration. Therefore, typical light microscopes mostly allow us to see the surface of the tissues, and details that are multiple cell layers deep are out of reach for many microscopes. This makes taking high-resolution optical images of microstructures deep inside tissues highly challenging.
